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CyFlow™ CD45 Purified

Application:	Flow cytometry, Immunocytochemistry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation, Western blot
Clone:	MEM-28
Alternative Name:	B220, LCA, T200
Antigen:	CD45
Clonality:	monoclonal
Isotype:	IgG1
Format/Fluorochrome:	Purified
Field of Interest:	Immunophenotyping, Phosphorylation
Source Species:	Mouse
Regulatory Status:	RUO
Target Species:	Human
Order number:	CD662607

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more

Product information "CyFlow™ CD45 Purified"

Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1 mL
Immunogen	Human thymocytes and T lymphocytes
Background Information	CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

Safety Data Sheet

Technical Data Sheet

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CyFlow™ CD45 Biotin

Antigen:	CD45
Clone:	MEM-28
Application:	Flow cytometry
Regulatory Status:	RUO
Target Species:	Human
Quantity:	0.1 mg

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