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CyFlow™ CD44 PE

CyFlow™ CD44 PE
Antigen: CD44
Alternative Name: H-CAM, Pgp-1
Clone: IM7
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Cat, Dog, Horse, Human, Mouse
Field of Interest: Immunophenotyping
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG2b
Order number: CY813253

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration Unit mg/mL Concentration 0.5 Quantity 0.1 mg Volume 0.2... more
CyFlow™ CD44 PE
Concentration Unitmg/mL
Quantity0.1 mg
ImmunogenDexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
Background InformationCD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells.
UsageThe reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Lesley J, Trowbridge IS: Genetic characterization of a polymorphic murine cell‑surface glycoprotein. Immunogenetics. 1982·Mar; 15(3):313‑20. <·PMID:·7068175·> | Si-Tahar M, Sitaraman S, Shibahara T, Madara JL: Negative regulation of epithelium‑neutrophil interactions via activation of CD44. Am·J·Physiol·Cell·Physiol. 2001·Mar; 280(3):C423‑32. <·PMID:·11171560·> | Legg JW, Lewis CA, Parsons M, Ng T, Isacke CM: A novel PKC‑regulated mechanism controls CD44 ezrin association and directional cell motility. Nat·Cell·Biol. 2002·Jun; 4(6):399‑407. <·PMID:·12032545·> | McKallip RJ, Do Y, Fisher MT, Robertson JL, Nagarkatti PS, Nagarkatti M: Role of CD44 in activation‑induced cell death: CD44‑deficient mice exhibit enhanced T cell response to conventional and superantigens. Int·Immunol. 2002·Sep; 14(9):1015‑26. <·PMID:·12202399·> | Xu H, Manivannan A, Liversidge J, Sharp PF, Forrester JV, Crane IJ: Involvement of CD44 in leukocyte trafficking at the blood‑retinal barrier. J·Leukoc·Biol. 2002·Dec; 72(6):1133‑41. <·PMID:·12488494·> | Katoh S, Matsumoto N, Kawakita K, Tominaga A, Kincade PW, Matsukura S: A role for CD44 in an antigen‑induced murine model of pulmonary eosinophilia. J·Clin·Invest. 2003·May; 111(10):1563‑70. <·PMID:·12750406·> | van Royen N, Voskuil M, Hoefer I, Jost M, de Graaf S, Hedwig F, Andert JP, Wormhoudt TA, Hua J, Hartmann S, Bode C, Buschmann I, Schaper W, van der Neut R, Piek JJ, Pals ST: CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization. Circulation. 2004·Apr·6; 109(13):1647‑5. <·PMID:·15023889·> | Larkin J, Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR: CD44 differentially activates mouse NK T cells and conventional T cells. J·Immunol. 2006·Jul·1; 177(1):268‑79. <·PMID:·16785522·> | Hegde VL, Singh NP, Nagarkatti PS, Nagarkatti M: CD44 mobilization in allogeneic dendritic cell‑T cell immunological synapse plays a key role in T cell activation. J·Leukoc·Biol. 2008·Jul; 84(1):134‑42. <·PMID:·18388297·>