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CyFlow™ CD45R Purified

CyFlow™ CD45R Purified
Antigen: CD45R
Clone: RA3-6B2
Application: Flow cytometry, Functional assays, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
Format/Fluorochrome: Purified
Target Species: Cat, Human, Mouse
Field of Interest: Immunophenotyping, Phosphorylation
Species of Origin: Rat
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG2a
Order number: CE555722

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more
CyFlow™ CD45R Purified
Concentration Unitmg/mL
Quantity0.1 mg
ImmunogenAbelson murine leukemia virus-induced pre-B tumor cells
Background InformationCD45R is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Watanabe Y, Akaike T: Activation signal induces the expression of B cell‑specific CD45R epitope (6B2) on murine T cells. Scand·J·Immunol. 1994·May; 39(5):419‑25. <·PMID:·7514808·> | Rada C, Ehrenstein MR, Neuberger MS, Milstein C: Hot spot focusing of somatic hypermutation in MSH2‑deficient mice suggests two stages of mutational targeting. Immunity. 1998·Jul; 9(1):135‑41. <·PMID:·9697843·> | Tsurui H, Nishimura H, Hattori S, Hirose S, Okumura K, Shirai T: Seven‑color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition. J·Histochem·Cytochem. 2000·May; 48(5):653‑62. <·PMID:·10769049·> | Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I: Lupus IgG VH4.34 antibodies bind to a 220‑kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J·Immunol. 2004·Apr·1; 172(7):4298‑307. <·PMID:·15034044·> | Montecino-Rodriguez E, Leathers H, Dorshkind K: Identification of a B‑1 B cell‑specified progenitor. Nat·Immunol. 2006·Mar; 7(3):293‑301. <·PMID:·16429139·> | Rothaeusler K, Baumgarth N: Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry. Cytometry·A. 2006·Apr; 69(4):249‑59. <·PMID:·16538653·> | Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ: Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi‑infected joint tissue. J·Immunol. 2012·Sep·1; 189(5):2488‑501. <·PMID:·22851707·>