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CyFlow™ CD5 APC
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Target Species: | Human |
| Regulatory Status: | RUO |
| Source Species: | Mouse |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | APC |
| Laser: | Red |
| Excitation Maximum: | 650 nm |
| Emission Maximum: | 660 nm |
| Isotype: | IgG2a |
| Antigen: | CD5 |
| Alternative Name: | Leu-1, T1 |
| Clone: | L17F12 |
| Order number: | CT154820 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
HLDA Workshop HLDA II Quantity 100 tests Volume 1.0 mL Immunogen Human Acute... more
Product information "CyFlow™ CD5 APC"
| HLDA Workshop | HLDA II |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Human Acute Lymphocytic Leukemia (ALL) T cells |
| Background Information | CD5 (T1) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
| Usage | The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
- CyFlow™ CD5 APC (L17F12) AZ292939 TDS US,CA EN.pdf
- CyFlow CD5 APC (CRIS1) CM995506 TDS RUO.pdf
- CyFlow CD5 APC (L17F12) CT154820 TDS RUO.pdf
- CyFlow CD5 APC (L17F12) AZ292939 TDS ASR EN.pdf
Instruction for Use
- CyFlow CD5 APC (L17F12) BU171249 IFU DE DE.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU CZ CZ.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU DE DE.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU DK DK.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU ES ES.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU FR FR.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU GB EN.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU GR EL.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU IT IT.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU NL NL.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU NO NO.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU PL PL.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU PT PT.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU RU RU.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU SE SV.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU SK SK.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU TR TR.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU CZ CZ.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU DK DK.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU ES ES.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU FR FR.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU GB EN.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU GR EL.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU IT IT.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU NL NL.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU NO NO.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU PL PL.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU PT PT.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU RU RU.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU SE SV.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU SK SK.pdf
- CyFlow CD5 APC (L17F12) BU171249 IFU TR TR.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU BG BG.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU HR HR.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU RO RO.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU SI SL.pdf
- CyFlow CD5 APC (L17F12) AZ902247 IFU RS SR.pdf
ECDoC
Certificate Of Analysis
- CyFlow CD5 APC AZ292939 COA 902500.pdf
- CyFlow CD5 APC BU171249 COA 902500.pdf
- CyFlow CD5 APC AZ292939 COA 903292.pdf
- CyFlow CD5 APC BU171249 COA 903292.pdf
- CyFlow CD5 APC BU171249 COA 903808.pdf
- CyFlow CD5 APC AZ292939 COA 903808.pdf
- CyFlow CD5 APC AZ902247 COA 904809.pdf
- CyFlow CD5 APC AZ292939 COA 904809.pdf
- CyFlow CD5 APC AZ292939 COA 907294.pdf
- CyFlow CD5 APC AZ902247 COA 907294.pdf
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