CyFlow™ CD1a APC

Antigen:	CD1a
Alternative Name:	CD1, HTA1, R4
Clone:	SK9
Application:	Flow cytometry
Format/Fluorochrome:	APC
Laser:	Red
Target Species:	Human
Field of Interest:	Immunophenotyping
Species of Origin:	Mouse
Regulatory Status:	RUO
Clonality:	monoclonal
Emission Maximum:	660 nm
Excitation Maximum:	650 nm
Isotype:	IgG2b
Order number:	CM362473

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA II Quantity 100 tests Volume 1 Immunogen Human thymocytes... more

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CyFlow™ CD1a APC

HLDA Workshop	HLDA II
Quantity	100 tests
Volume	1
Immunogen	Human thymocytes
Background Information	CD1a, together with CD1b and CD1c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Usage	The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage Buffer	The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

Specific References

| Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non‑T cells in the acquired immunodeficiency syndrome. Am·J·Pathol. 1985·Sep; 120(3):371‑9. <·PMID:·3898858·> | Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002·Apr·15; 99(8):2859‑68. <·PMID:·11929776·> | Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int·Immunol. 2003·Sep; 15(9):1105‑16. <·PMID:·12917263·> | Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J·Immunol. 2007·Jun·1; 178(11):6958‑67. <·PMID:·17513745·> | Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol·Cell·Biol. 2009·Jul; 87(5):419‑27. <·PMID:·19223853·> | Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7‑ and TLR9‑mediated IFN‑α: production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS·Pathog. 2013; 9(7):e1003530. <·PMID:·23935491·>

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Sysmex Flow Cytometry Other European Country!