Welcome to
Sysmex Flow Cytometry Other European Country!

For ordering please make sure you are in your local shop.
If you are from Other European Country then please continue.
Otherwise please go to your country.

Go to my country Continue

Article successfully added.

CyFlow™ CD11a FITC

CyFlow™ CD11a FITC
Application: Flow cytometry
Clonality: monoclonal
Format/Fluorochrome: FITC
Target Species: Human
Regulatory Status: RUO
Laser: Blue
Excitation Maximum: 490 to 495 nm
Emission Maximum: 518 nm
Source Species: Mouse
Field of Interest: Immunophenotyping
Isotype: IgG1
Antigen: CD11a
Alternative Name: LFA-1
Clone: MEM-25
Order number: BD356093
Quantity 100 tests Volume 2.0 mL Immunogen Leukocytes of a patient suffering from... more
Product information "CyFlow™ CD11a FITC"
Quantity100 tests
Volume2.0 mL
ImmunogenLeukocytes of a patient suffering from LGL-type leukemia
Background InformationCD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αLβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 20·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Similar products
FITC
CyFlow™ CD1a FITC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
PE
CyFlow™ CD1a PE
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
APC
CyFlow™ CD1a APC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1a Purified
Antigen: CD1a
Clone: SK9
Application: Flow cytometry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
FITC
CyFlow™ CD1b FITC
Antigen: CD1b
Clone: SN13
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1b Purified
Antigen: CD1b
Clone: SN13
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
PE
CyFlow™ CD1c PE
Antigen: CD1c
Clone: L161
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1c Purified
Antigen: CD1c
Clone: L161
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg

 

Need more information?
Need more information?
Service Hotline | Contact | Benefits
Service hotline
tel: +49 (40) 527 26 0 Mon-Fri, 9 am - 5 pm

Contact
Use our contact form