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CyFlow™ CD18 PE
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Target Species: | Human |
| Regulatory Status: | RUO |
| Laser: | Blue, Green, Yellow |
| Source Species: | Mouse |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | PE |
| Excitation Maximum: | 496 nm, 565 nm |
| Emission Maximum: | 576 nm |
| Isotype: | IgG1 |
| Antigen: | CD18 |
| Alternative Name: | b2 integrin |
| Clone: | MEM-148 |
| Order number: | AS957495 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Quantity 100 tests Volume 2.0 mL Immunogen Peripheral blood mononuclear cells... more
Product information "CyFlow™ CD18 PE"
| Quantity | 100 tests |
| Volume | 2.0 mL |
| Immunogen | Peripheral blood mononuclear cells |
| Background Information | CD18 (integrin β2 subunit) forms heterodimers with four types of CD11 molecule to constitute leukocyte (β2) integrins: αLβ2 (CD11a/CD18, LFA-1), αMβ2 (CD11b/CD18, Mac-1, CR3), αXβ2 (CD11c/CD18) and αDβ2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |
| Usage | The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 20·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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