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CyFlow™ CD44 Purified

CyFlow™ CD44 Purified
Antigen: CD44
Alternative Name: H-CAM, Pgp-1
Clone: MEM-263
Application: Flow cytometry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Dog, Human, Pig
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: BL322560

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen COS-7 African green... more
CyFlow™ CD44 Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenCOS-7 African green monkey kidney cells
SpecifityThe mouse monoclonal antibody MEM-263 recognizes extracellular (N-terminal) domain of standard CD44, a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.
Background InformationCD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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