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CyFlow™ CD47 Pacific Blue™

CyFlow™ CD47 Pacific Blue™
Application: Flow cytometry
Clonality: monoclonal
Target Species: Human, Non-Human Primates, Pig
Regulatory Status: RUO
Source Species: Mouse
Field of Interest: Immunophenotyping
Format/Fluorochrome: Pacific Blue™
Laser: Violet
Excitation Maximum: 400 to 410 nm
Emission Maximum: 455 nm
Isotype: IgM
Antigen: CD47
Alternative Name: IAP
Clone: MEM-122
Order number: BL379138
Quantity 100 tests Volume 0.4 mL Immunogen COS-7 African green monkey kidney cells... more
Product information "CyFlow™ CD47 Pacific Blue™"
Quantity100 tests
Volume0.4 mL
ImmunogenCOS-7 African green monkey kidney cells
Background InformationCD47 (IAP; integrin-associated protein) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (SIRP α; signal regulatory protein α), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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