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CyFlow™ CD71 Purified

CyFlow™ CD71 Purified
Antigen: CD71
Alternative Name: T9, TFR, TRFR
Clone: MEM-189
Application: Flow cytometry, Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Endocytosis, Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: AQ912926

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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EUROBIOTECH2017

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*1 Offer valid until 23/09/2017
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more
CyFlow™ CD71 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenHuman Acute Myelogenous Leukemia (AML) KG-1 cells
Background InformationCD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
Storage BufferThe reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGK, Zola H (Eds): Leucocyte Typing VI. Garland·Publishing·Inc,·New·York. 1997; 1‑1342. <·NLM·ID:·9712219·> | Rouault TA: How mammals acquire and distribute iron needed for oxygen‑based metabolism. PLoS·Biol. 2003·Dec; 1(3):E79. <·PMID:·14691550·> | Taketani S: Aquisition, mobilization and utilization of cellular iron and heme: endless findings and growing evidence of tight regulation. Tohoku·J·Exp·Med. 2005·Apr; 205(4):297‑318. <·PMID:·15750326·> | Graham RM, Chua AC, Herbison CE, Olynyk JK, Trinder D: Liver iron transport. World·J·Gastroenterol. 2007·Sep·21; 13(35):4725‑36. <·PMID:·17729394·> | Graham RM, Reutens GM, Herbison CE, Delima RD, Chua AC, Olynyk JK, Trinder D: Transferrin receptor 2 mediates uptake of transferrin‑bound and non‑transferrin‑bound iron. J·Hepatol. 2008·Feb; 48(2):327‑34. <·PMID:·18083267·>

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