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CyFlow™ CD80 Purified

CyFlow™ CD80 Purified
Antigen: CD80
Alternative Name: B7- B7-1, BB1
Clone: 16-10A1
Application: Flow cytometry, Functional assays, Immunohistochemistry (frozen sections), Immunoprecipitation
Format/Fluorochrome: Purified
Target Species: Dog, Mouse
Field of Interest: Immunophenotyping, MHC
Species of Origin: Hamster
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG2
Order number: CN558009

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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*1
EUROBIOTECH2017

Order two antibodies and get the lower-priced one for free

*1 Offer valid until 23/09/2017
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more
CyFlow™ CD80 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenCD80-transfected CHO cell line
Background InformationCD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CD152 (CTLA-4). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Horspool JH, Perrin PJ, Woodcock JB, Cox JH, King CL, June CH, Harlan DM, St Louis DC, Lee KP: Nucleic acid vaccine‑induced immune responses require CD28 costimulation and are regulated by CTLA4. J·Immunol. 1998·Mar·15; 160(6):2706‑14. <·PMID:·9510170·> | Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L: CD80+Gr‑1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J·Immunol. 2002·Sep·15; 169(6):3180‑90. <·PMID:·12218136·> | Gueirard P, Ave P, Balazuc AM, Thiberge S, Huerre M, Milon G, Guiso N: Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract. Infect·Immun. 2003·Jul; 71(7):4137‑43. <·PMID:·12819105·> | Quah B, Ni K, O'Neill HC: In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity. Int·Immunol. 2004·Apr; 16(4):567‑77. <·PMID:·15039387·> | Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P: Induction of B7‑1 in podocytes is associated with nephrotic syndrome. J·Clin·Invest. 2004·May; 113(10):1390‑7. <·PMID:·15146236·> | Paust S, Lu L, McCarty N, Cantor H: Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc·Natl·Acad·Sci·USA. 2004·Jul·13; 101(28):10398‑403. <·PMID:·15235129·> | Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR: Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J·Am·Soc·Nephrol. 2005·Jul; 16(7):2012‑22. <·PMID:·15944341·> | Mukherjee S, Ahmed A, Malu S, Nandi D: Modulation of cell cycle progression by CTLA4‑CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL‑2. J·Leukoc·Biol. 2006·Jul; 80(1):66‑74. <·PMID:·16624934·>

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