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CyFlow™ CD95 Purified

CyFlow™ CD95 Purified
Antigen: CD95
Alternative Name: APO-1, Fas, TNFRSF6
Clone: EOS9.1
Application: Functional assays
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgM
Order number: CP421037

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen P815 cells... more
CyFlow™ CD95 Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenP815 cells transfected with human CD95
SpecifityThe mouse monoclonal antibody EOS9.1 recognizes CD95 antigen, a 46 kDa glycoprotein of the tumor necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.
Background InformationCD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Storage BufferThe reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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