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CyFlow™ CD105 Purified
| Application: | Flow cytometry, Immunohistochemistry (frozen sections), Immunoprecipitation, Western blot |
| Clonality: | monoclonal |
| Regulatory Status: | RUO |
| Field of Interest: | Immunophenotyping, MHC |
| Format/Fluorochrome: | Purified |
| Isotype: | IgG2a |
| Target Species: | Mouse |
| Source Species: | Rat |
| Antigen: | CD105 |
| Alternative Name: | Endoglin |
| Clone: | MJ7/18 |
| Order number: | AP974049 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ CD105 Purified"
| Concentration Unit | mg/mL |
| Concentration | 1 |
| Quantity | 0.1 mg |
| Volume | 0.1 mL |
| Immunogen | Inflamed mouse skin |
| Background Information | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonizes the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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