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CyFlow™ CD222 Alexa Fluor™ 647
| Application: | Flow cytometry |
| Format/Fluorochrome: | Alexa Fluor™ 647 |
| Alternative Name: | CIMPR, IGF2R, M6P-R, MPR1 |
| Antigen: | CD222 |
| Field of Interest: | Immunophenotyping, Signaling |
| Emission Maximum: | 665 nm |
| Target Species: | Human, Non-Human Primates |
| Clonality: | monoclonal |
| Isotype: | IgG1 |
| Excitation Maximum: | 650 nm |
| Laser: | Red |
| Source Species: | Mouse |
| Regulatory Status: | RUO |
| Clone: | MEM-238 |
| Order number: | AQ486061 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Quantity 100 tests Volume 0.4 mL Immunogen Recombinant Vaccinia virus encoding CD222... more
Product information "CyFlow™ CD222 Alexa Fluor™ 647"
| Quantity | 100 tests |
| Volume | 0.4 mL |
| Immunogen | Recombinant Vaccinia virus encoding CD222 |
| Background Information | CD222 (CIMPR; cation-independent mannose 6-phosphate receptor or IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-β, last but not least CD222 serves as a receptor for heparanase and even for Listeria. |
| Usage | The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
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