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CyFlow™ FoxP3 Alexa Fluor™ 488
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Target Species: | Human, Mouse |
| Regulatory Status: | RUO |
| Laser: | Blue |
| Source Species: | Mouse |
| Isotype: | IgG1 |
| Format/Fluorochrome: | Alexa Fluor™ 488 |
| Excitation Maximum: | 495 nm |
| Emission Maximum: | 519 nm |
| Field of Interest: | Transcription |
| Antigen: | FoxP3 |
| Alternative Name: | foxp3 ,Forkhead box P3 ,IPEX ,JM2 ,MGC141961 ,MGC141963 ,PIDX ,XPID |
| Clone: | 3G3 |
| Order number: | BX764200 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 0,5 Quantity 0.1 mg Volume 0.2 mL... more
Product information "CyFlow™ FoxP3 Alexa Fluor™ 488"
| Concentration Unit | mg/mL |
| Concentration | 0,5 |
| Quantity | 0.1 mg |
| Volume | 0.2 mL |
| Immunogen | Full-length His-tagged recombinant murine FoxP3 |
| Background Information | FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. |
| Usage | The reagent is designed for Flow Cytometry analysis. Suggested working usage is 4·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator. |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
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