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CyFlow™ FoxP3 PE

CyFlow™ FoxP3 PE
Application: Flow cytometry
Excitation Maximum: 496 nm, 565 nm
Alternative Name: foxp3 ,Forkhead box P3 ,IPEX ,JM2 ,MGC141961 ,MGC141963 ,PIDX ,XPID
Antigen: FoxP3
Field of Interest: Transcription
Target Species: Human, Mouse
Isotype: IgG1
Emission Maximum: 576 nm
Laser: Blue, Green, Yellow
Clonality: monoclonal
Format/Fluorochrome: PE
Source Species: Mouse
Regulatory Status: RUO
Clone: 3G3
Order number: BV376397
Concentration Unit mg/mL Concentration 0,5 Quantity 0.1 mg Volume 0.2 mL... more
Product information "CyFlow™ FoxP3 PE"
Concentration Unitmg/mL
Concentration0,5
Quantity0.1 mg
Volume0.2 mL
ImmunogenFull-length His-tagged recombinant murine FoxP3
Background InformationFoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.
UsageThe reagent is designed for Flow Cytometry analysis. Suggested working usage is 3·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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