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CyFlow™ Notch 1 PE
Application: | Flow cytometry |
Clonality: | monoclonal |
Target Species: | Human, Mouse |
Regulatory Status: | RUO |
Laser: | Blue, Green, Yellow |
Source Species: | Mouse |
Format/Fluorochrome: | PE |
Excitation Maximum: | 496 nm, 565 nm |
Emission Maximum: | 576 nm |
Isotype: | IgG1 |
Field of Interest: | Transcription |
Antigen: | Notch 1 |
Clone: | mN1A |
Order number: | AE976102 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 0,1 Quantity 0.1 mg Volume 1.0 mL... more
Product information "CyFlow™ Notch 1 PE"
Concentration Unit | mg/mL |
Concentration | 0,1 |
Quantity | 0.1 mg |
Volume | 1.0 mL |
Immunogen | GST fusion protein containing cdc10-NCR region of mouse Notch 1 |
Background Information | Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged1 (CD339), and Jagged2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus. |
Usage | The reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator. |
Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
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