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CyFlow™ CD5 Pacific Blue™
Application: | Flow cytometry |
Clonality: | monoclonal |
Target Species: | Human |
Regulatory Status: | RUO |
Source Species: | Mouse |
Field of Interest: | Immunophenotyping |
Format/Fluorochrome: | Pacific Blue™ |
Laser: | Violet |
Excitation Maximum: | 400 to 410 nm |
Emission Maximum: | 455 nm |
Isotype: | IgG2a |
Antigen: | CD5 |
Alternative Name: | Leu-1, T1 |
Clone: | CRIS1 |
Order number: | AH799840 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
HLDA Workshop HLDA I—WS Code T 29 HLDA III—WS Code T 530 Quantity 100 tests Volume... more
Product information "CyFlow™ CD5 Pacific Blue™"
HLDA Workshop | HLDA I—WS Code T 29 HLDA III—WS Code T 530 |
Quantity | 100 tests |
Volume | 0.4 mL |
Immunogen | Stimulated human leukocytes |
Background Information | CD5 (T1) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
Usage | The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
- CyFlow™ CD5 Pacific Blue™ (L17F12) BJ017034 TDS US,CA EN.pdf
- CyFlow CD5 Pacific Blue (CRIS1) AH799840 TDS RUO.pdf
- CyFlow CD5 Pacific Blue (L17F12) BJ017034 TDS ASR EN.pdf
Instruction for Use
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU DE DE.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU CZ CZ.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU DE DE.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU DK DK.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU ES ES.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU FR FR.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU GB EN.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU GR EL.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU IT IT.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU NL NL.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU NO NO.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU PL PL.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU PT PT.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU RU RU.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU SE SV.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU SK SK.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU TR TR.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU CZ CZ.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU DK DK.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU ES ES.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU FR FR.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU GB EN.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU GR EL.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU IT IT.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU NL NL.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU NO NO.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU PL PL.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU PT PT.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU RU RU.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU SE SV.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU SK SK.pdf
- CyFlow CD5 Pacific Blue (L17F12) CA236265 IFU TR TR.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU BG BG.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU HR HR.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU RO RO.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU SI SL.pdf
- CyFlow CD5 Pacific Blue (L17F12) AX332418 IFU RS SR.pdf
ECDoC
Certificate Of Analysis
- CyFlow CD5 Pacific Blue BJ017034 COA 902540.pdf
- CyFlow™ CD5 Pacific Blue™_CA236265_COA_901081.pdf
- CyFlow CD5 Pacific Blue BJ017034 COA 903471.pdf
- CyFlow CD5 Pacific Blue AX332418 COA 904904.pdf
- CyFlow CD5 Pacific Blue BJ017034 COA 904904.pdf
- CyFlow CD5 Pacific Blue CA236265 COA 904904.pdf
- CyFlow CD5 Pacific Blue BJ017034 COA 906029.pdf
- CyFlow CD5 Pacific Blue CA236265 COA 906029.pdf
- CyFlow CD5 Pacific Blue AX332418 COA 906029.pdf
- CyFlow CD5 Pacific Blue BJ017034 COA 907851.pdf
- CyFlow CD5 Pacific Blue AX332418 COA 907851.pdf
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