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CyFlow™ CD84 PE

CyFlow™ CD84 PE
Antigen: CD84
Alternative Name: SLAMF5
Clone: CD84.1.21
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG2a
Order number: AS246227

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Quantity 100 tests Volume 1 Immunogen CD84-transfected 300.19 cell line Background... more
CyFlow™ CD84 PE
Quantity100 tests
ImmunogenCD84-transfected 300.19 cell line
Background InformationCD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C: Cell surface receptors Ly‑9 and CD84 recruit the X‑linked lymphoproliferative disease gene product SAP. Blood. 2001·Jun·15; 97(12):3867‑74. <·PMID:·11389028·> | Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C: Characterization of SH2D1A missense mutations identified in X‑linked lymphoproliferative disease patients. J·Biol·Chem. 2001·Sep·28; 276(39):36809‑16. <·PMID:·11477068·> | Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P: CD84 functions as a homophilic adhesion molecule and enhances IFN‑gamma secretion: adhesion is mediated by Ig‑like domain 1. J·Immunol. 2001·Oct·1; 167(7):3668‑76. <·PMID:·11564780·> | Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C: Structural basis for the interaction of the free SH2 domain EAT‑2 with SLAM receptors in hematopoietic cells. EMBO·J. 2001·Nov·1; 20(21):5840‑52. <·PMID:·11689425·> | Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P: CD229 (Ly{09} lymphocyte cell surface receptor interacts homophilically through its N‑terminal domain and relocalizes to the immunological synapse. J·Immunol. 2005·Jun·1; 174(11):7033‑42. <·PMID:·15905546·>