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CyFlow™ CD94 PE

CyFlow™ CD94 PE
Antigen: CD94
Alternative Name: Kp43
Clone: HP-3D9
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG1
Order number: AX430444

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA V—WS Code NK82 Quantity 100 tests Volume 1 Immunogen Cultured... more
CyFlow™ CD94 PE
HLDA WorkshopHLDA V—WS Code NK82
Quantity100 tests
ImmunogenCultured human NK cells
Background InformationCD94 (KLRD1; killer cell lectin-like receptor D1) is a transmembrane glycoprotein of the C-type lectin family, which forms disulfide-linked heterodimers with NKG2A, B, C, E, H proteins, constituting functionally distinct receptors of NK cells and related cell types. CD94/NKG2A and CD94/NKG2B heterodimers serve as inhibitory, whereas CD94/NKG2C and CD94/NKG2E as activating receptors. The ligand for CD94/NKG2 complexes has been identified as HLA-E. Extent of CD94 expression on NK cell surface can be used to demonstrate their progress through the differentiation process.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL: CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA‑A, HLA‑B, and HLA‑C allotypes. Immunity. 1996·Aug; 5(2):163‑72. <·PMID:·8769479·> | Seo N, Tokura Y, Ishihara S, Takeoka Y, Tagawa S, Takigawa M: Disordered expression of inhibitory receptors on the NK1‑type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites. Clin·Exp·Immunol. 2000·Jun; 120(3):413‑9. <·PMID:·10844517·> | Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, Mantouvalos HP, Beer AE: Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum·Reprod. 2001·May; 16(5):855‑61. <·PMID:·11331628·> | Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M: Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3‑mediated stimulation. J·Leukoc·Biol. 2001·Aug; 70(2):219‑24. <·PMID:·11493613·> | Wada H, Matsumoto N, Maenaka K, Suzuki K, Yamamoto K: The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA‑E through mostly shared but partly distinct sets of HLA‑E residues. Eur·J·Immunol. 2004·Jan; 34(1):81‑90. <·PMID:·14971033·> | Bovenschen HJ, Van De Kerkhof PC, Gerritsen WJ, Seyger MM: The role of lesional T cells in recalcitrant psoriasis during infliximab therapy. Eur·J·Dermatol. 2005·Nov-Dec; 15(6):454‑8. <·PMID:·16280298·> | Hallermalm K, Seki K, De Geer A, Motyka B, Bleackley RC, Jager MJ, Froelich CJ, Kiessling R, Levitsky V, Levitskaya J: Modulation of the tumor cell phenotype by IFN‑gamma results in resistance of uveal melanoma cells to granule‑mediated lysis by cytotoxic lymphocytes. J·Immunol. 2008·Mar·15; 180(6):3766‑74. <·PMID:·18322182·> | Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA: CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK‑cell subsets. Blood. 2010·Jan·14; 115(2):274‑81. <·PMID:·19897577·>