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CyFlow™ CD105 PE

CyFlow™ CD105 PE
Application: Flow cytometry
Laser: Blue, Green, Yellow
Alternative Name: Endoglin
Antigen: CD105
Target Species: Human, Pig
Isotype: IgG2a
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Clonality: monoclonal
Format/Fluorochrome: PE
Field of Interest: Immunophenotyping
Source Species: Mouse
Regulatory Status: RUO
Clone: MEM-229
Order number: AS987399
Quantity 100 tests Volume 2.0 mL Immunogen Recombinant Vaccinia virus containing the... more
Product information "CyFlow™ CD105 PE"
Quantity100 tests
Volume2.0 mL
ImmunogenRecombinant Vaccinia virus containing the human CD105 cDNA
Background InformationCD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonizes the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 20·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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