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CyFlow™ CD148 PE
| Application: | Flow cytometry |
| Laser: | Blue, Green, Yellow |
| Alternative Name: | DEP-1, HPTP-a, SCC1 |
| Antigen: | CD148 |
| Field of Interest: | Immunophenotyping, Phosphorylation |
| Emission Maximum: | 576 nm |
| Excitation Maximum: | 496 nm, 565 nm |
| Clonality: | monoclonal |
| Format/Fluorochrome: | PE |
| Source Species: | Mouse |
| Isotype: | IgG2b |
| Regulatory Status: | RUO |
| Target Species: | Human |
| Clone: | MEM-CD148/05 |
| Order number: | BH775758 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Quantity 100 tests Volume 1.0 mL Immunogen Human recombinant CD148 (amino acids... more
Product information "CyFlow™ CD148 PE"
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Human recombinant CD148 (amino acids 1-444) |
| Background Information | CD148 (HPTP-eta, DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leukocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes. |
| Usage | The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
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