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CyFlow™ CD152 PE

CyFlow™ CD152 PE
Application: Flow cytometry
Laser: Blue, Green, Yellow
Alternative Name: CTLA-4, CTL Ag 4
Antigen: CD152
Isotype: IgG2a
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Clonality: monoclonal
Format/Fluorochrome: PE
Field of Interest: Immunophenotyping
Source Species: Mouse
Regulatory Status: RUO
Target Species: Human
Clone: BNI3
Order number: CV021049
Quantity 100 tests Volume 1.0 mL Immunogen Human CD152-IgG heavy chain fusion protein... more
Product information "CyFlow™ CD152 PE"
Quantity100 tests
Volume1.0 mL
ImmunogenHuman CD152-IgG heavy chain fusion protein
Background InformationCD152 (CTLA-4) is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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