Article successfully added.
CyFlow™ CD262 Purified
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Target Species: | Human |
| Regulatory Status: | RUO |
| Source Species: | Mouse |
| Field of Interest: | Apoptosis, Immunophenotyping |
| Format/Fluorochrome: | Purified |
| Isotype: | IgG1 |
| Antigen: | CD262 |
| Alternative Name: | DR5, TNFRSF10b, TRAILR2, TRICK2 |
| Clone: | DR5-01-1 |
| Order number: | CP234283 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ CD262 Purified"
| Concentration Unit | mg/mL |
| Concentration | 1 |
| Quantity | 0.1 mg |
| Volume | 0.1 mL |
| Immunogen | Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5 |
| Background Information | CD262 (TRAIL-R2 or DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and APO2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Safety Data Sheet
Technical Data Sheet
Similar products
FITC
CyFlow™ CD1a FITC
| Antigen: | CD1a |
| Clone: | SK9 |
| Application: | Flow cytometry |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 100 tests |
PE
CyFlow™ CD1a PE
| Antigen: | CD1a |
| Clone: | SK9 |
| Application: | Flow cytometry |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 100 tests |
APC
CyFlow™ CD1a APC
| Antigen: | CD1a |
| Clone: | SK9 |
| Application: | Flow cytometry |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 100 tests |
Purified
CyFlow™ CD1a Purified
| Antigen: | CD1a |
| Clone: | SK9 |
| Application: | Flow cytometry, Immunoprecipitation |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 0.1 mg |
FITC
CyFlow™ CD1b FITC
| Antigen: | CD1b |
| Clone: | SN13 |
| Application: | Flow cytometry |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 100 tests |
Purified
CyFlow™ CD1b Purified
| Antigen: | CD1b |
| Clone: | SN13 |
| Application: | Flow cytometry, Immunohistochemistry, Immunoprecipitation |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 0.1 mg |
PE
CyFlow™ CD1c PE
| Antigen: | CD1c |
| Clone: | L161 |
| Application: | Flow cytometry |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 100 tests |
Purified
CyFlow™ CD1c Purified
| Antigen: | CD1c |
| Clone: | L161 |
| Application: | Flow cytometry, Immunohistochemistry, Immunoprecipitation |
| Regulatory Status: | RUO |
| Target Species: | Human | Quantity: | 0.1 mg |