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CyFlow™ ABRA1 Purified
| Application: | Flow cytometry, Immunoprecipitation, Western blot |
| Clonality: | monoclonal |
| Target Species: | Human |
| Regulatory Status: | RUO |
| Source Species: | Mouse |
| Format/Fluorochrome: | Purified |
| Isotype: | IgG |
| Antigen: | ABRA1 |
| Clone: | ABRA1-01 |
| Field of Interest: | Adaptor proteins, Transcription |
| Order number: | AP667270 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of... more
Product information "CyFlow™ ABRA1 Purified"
ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
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