CyFlow™ ABRA1 Purified

Antigen:	ABRA1
Clone:	ABRA1-01
Application:	Flow cytometry, Immunoprecipitation, Western blot
Format/Fluorochrome:	Purified
Target Species:	Human
Field of Interest:	Adaptor proteins, Transcription
Species of Origin:	Mouse
Regulatory Status:	RUO
Clonality:	monoclonal
Isotype:	IgG
Order number:	AP667270

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more

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CyFlow™ ABRA1 Purified

Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1
Immunogen	Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Background Information	ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

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Specific References

| Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007·May·25; 316(5828):1194‑8. <·PMID:·17525340·> | Liu Z, Wu J, Yu X: CCDC98 targets BRCA1 to DNA damage sites. Nat·Struct·Mol·Biol. 2007·Aug; 14(8):716‑20. <·PMID:·17643121·> | Wang B, Elledge SJ: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc·Natl·Acad·Sci·USA. 2007·Dec·26; 104(52):20759‑63. <·PMID:·18077395·> | Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA: Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene. 2009·Apr·23; 28(16):1843‑52. <·PMID:·19305427·>

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Sysmex Flow Cytometry Other European Country!