CyFlow™ ABRA1 Purified

Antigen:	ABRA1
Clone:	ABRA1-01
Application:	Flow cytometry, Immunoprecipitation, Western blot
Format/Fluorochrome:	Purified
Target Species:	Human
Field of Interest:	Adaptor proteins, Transcription
Species of Origin:	Mouse
Regulatory Status:	RUO
Clonality:	monoclonal
Isotype:	IgG

Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1
Immunogen	Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Background Information	ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

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