CyFlow™ AGPS Purified
| Antigen: | AGPS |
| Clone: | AGPS-03 |
| Application: | Flow cytometry, Western blot |
| Format/Fluorochrome: | Purified |
| Target Species: | Human |
| Field of Interest: | Others |
| Species of Origin: | Mouse |
| Regulatory Status: | RUO |
| Clonality: | monoclonal |
| Isotype: | IgG2a |
| Concentration Unit | mg/mL |
| Concentration | 1 |
| Quantity | 0.1 mg |
| Volume | 0.1 |
| Immunogen | Recombinant human AGPS (amino acids 158-384) |
| Background Information | AGPS (alkylglycerone phosphate synthase) is an enzyme that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetone phosphate (acyl-DHAP) is converted to alkyl-DHAP by addition of a long chain alcohol and removal of a long-chain acid anion. The protein is localized to the inner side of the peroxisomal membrane and requires FAD as a cofactor. Mutations in AGPS gene have been associated with type 3 of rhizomelic chondrodysplasia punctata (RCDP3), and Zellweger syndrome. Higher expression of AGPS was observed in BCR/ABL positive leukemias and it was also described to be associated with higher risk of relapse. |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
| Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR: Classification, subtype discovery, and prediction of outcome in pediatric acutelymphoblastic leukemia by gene expression profiling. Cancer·Cell. 2002·Mar; 1(2):133‑43. <·PMID:·12086872·> | Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, Min DJ, Potter JW, Harvey R, Hunger SP, Seibel N, Raetz EA, Pieters R, Horstmann MA, Relling MV, den Boer ML, Willman CL, Carroll WL: Gene expression signatures predictive of early response and outcome in high‑risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study. J·Clin·Oncol. 2008·Sep·20; 26(27):4376‑84. <·PMID:·18802149·> | Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T: Plasmalogen synthesis is regulated via alkyl‑dihydroxyacetonephosphate‑synthase by amyloid precursor protein processing and is affected in Alzheimer'sdisease. J·Neurochem. 2011·Mar; 116(5):916‑25. <·PMID:·21214572·> | Itzkovitz B, Jiralerspong S, Nimmo G, Loscalzo M, Horovitz DD, Snowden A, Moser A, Steinberg S, Braverman N: Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3. Hum·Mutat. 2012·Jan; 33(1):189‑97. <·PMID:·21990100·>
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