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CyFlow™ GRAP2 Purified

CyFlow™ GRAP2 Purified
Application: Flow cytometry, Immunoprecipitation, Western blot
Clonality: monoclonal
Target Species: Human
Regulatory Status: RUO
Source Species: Mouse
Format/Fluorochrome: Purified
Isotype: IgG2a
Field of Interest: Adaptor proteins
Antigen: GRAP2
Alternative Name: GADS
Clone: UW40
Order number: CE576626
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ GRAP2 Purified"
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenGST fusion human GRAP2/GADS protein
Background InformationGRAP2; Grb2-related adaptor protein 2 or GADS; Grb2-related adaptor downstream of Shc, is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2 (GADS) plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2 (GADS) also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2 (GADS) shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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