Welcome to
Sysmex Flow Cytometry Other European Country!

For ordering please make sure you are in your local shop.
If you are from Other European Country then please continue.
Otherwise please go to your country.

Go to my country Continue

Article successfully added.

CyFlow™ IFN-gamma FITC

CyFlow™ IFN-gamma FITC
Application: Flow cytometry
Clonality: monoclonal
Format/Fluorochrome: FITC
Target Species: Human, Non-Human Primates
Regulatory Status: RUO
Laser: Blue
Excitation Maximum: 490 to 495 nm
Emission Maximum: 518 nm
Source Species: Mouse
Isotype: IgG1
Field of Interest: Signaling
Antigen: IFN-γ
Clone: 4S.B3
Order number: AE092283
Quantity 100 tests Volume 0.4 mL Immunogen Interferon γ derived from human leukocytes... more
Product information "CyFlow™ IFN-gamma FITC"
Quantity100 tests
Volume0.4 mL
ImmunogenInterferon γ derived from human leukocytes
Background InformationInterferon γ (IFN-γ) is an important regulator of the immune response, produced in activated Th1 cells and NK cells, particularly in response to IL-2, TNF-α and IL-12; its production is suppressed by IL-4, IL-10, and TGF-β. The production of IFN-γ is activated by specific antigens or mitogens through the T cell antigen receptor. IFN-γ polypeptide forms: 40-60 kDa forms are observable under non-denaturing conditions as dimers and trimers; 20 kDa and 25 kDa forms exist due to variable glycosylation. IFN-γ belongs to the type II interferons, also called immune IFN. IFN-γ shows antiviral activity and has important immunoregulatory functions. It is a potent activator of macrophages and had antiproliferative effects on transformed cells. IFN-γ plays an important role in regulating B cell differentiation by simultaneously stimulating class switch recombination to the IgG3 and IgG2a isotypes while represing class switch recombination to the IgE and IgG1 isotypes. It also appears to promote antigen presentation by B cells through its effects on MHC. Binding of IFN-γ to its receptor increases the expression of class I MHC on all somatic cells. It also enhances the expression of class II MHC on antigen-presenting cells. IFN-γ is the major means by which T cells activate macrophages, increasing their ability to kill bacteria, parasites, and tumors. The activation of macrophages by IFN-γ is essential for the elimination of bacteria that replicate within the phagosomes of macrophages (f.e. Mycobacteria and Listeria monocytogenes). IFN-γ can potentiate the high antiviral and antitumor effects of the type I interferons (IFN-α, IFN-β). IFN-γ may also activate neutrophils and NK cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Similar products
FITC
CyFlow™ CD1a FITC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
PE
CyFlow™ CD1a PE
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
APC
CyFlow™ CD1a APC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1a Purified
Antigen: CD1a
Clone: SK9
Application: Flow cytometry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
FITC
CyFlow™ CD1b FITC
Antigen: CD1b
Clone: SN13
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1b Purified
Antigen: CD1b
Clone: SN13
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
PE
CyFlow™ CD1c PE
Antigen: CD1c
Clone: L161
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1c Purified
Antigen: CD1c
Clone: L161
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg

 

Need more information?
Need more information?
Service Hotline | Contact | Benefits
Service hotline
tel: +49 (40) 527 26 0 Mon-Fri, 9 am - 5 pm

Contact
Use our contact form