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CyFlow™ IFN-gamma Purified

CyFlow™ IFN-gamma Purified
Application: Enzyme-linked immunosorbent assay, Flow cytometry, Functional assays, Immunocytochemistry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation, Radioimmunoassay, Western blot
Antigen: IFN-γ
Field of Interest: Signaling
Target Species: Human, Non-Human Primates
Clonality: monoclonal
Isotype: IgG1
Format/Fluorochrome: Purified
Source Species: Mouse
Regulatory Status: RUO
Clone: 4S.B3
Order number: AJ218636
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ IFN-gamma Purified"
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenInterferon γ derived from human leukocytes
Background InformationInterferon γ (IFN-γ) is an important regulator of the immune response, produced in activated Th1 cells and NK cells, particularly in response to IL-2, TNF-α and IL-12; its production is suppressed by IL-4, IL-10, and TGF-β. The production of IFN-γ is activated by specific antigens or mitogens through the T cell antigen receptor. IFN-γ polypeptide forms: 40-60 kDa forms are observable under non-denaturing conditions as dimers and trimers; 20 kDa and 25 kDa forms exist due to variable glycosylation. IFN-γ belongs to the type II interferons, also called immune IFN. IFN-γ shows antiviral activity and has important immunoregulatory functions. It is a potent activator of macrophages and had antiproliferative effects on transformed cells. IFN-γ plays an important role in regulating B cell differentiation by simultaneously stimulating class switch recombination to the IgG3 and IgG2a isotypes while represing class switch recombination to the IgE and IgG1 isotypes. It also appears to promote antigen presentation by B cells through its effects on MHC. Binding of IFN-γ to its receptor increases the expression of class I MHC on all somatic cells. It also enhances the expression of class II MHC on antigen-presenting cells. IFN-γ is the major means by which T cells activate macrophages, increasing their ability to kill bacteria, parasites, and tumors. The activation of macrophages by IFN-γ is essential for the elimination of bacteria that replicate within the phagosomes of macrophages (f.e. Mycobacteria and Listeria monocytogenes). IFN-γ can potentiate the high antiviral and antitumor effects of the type I interferons (IFN-α, IFN-β). IFN-γ may also activate neutrophils and NK cells.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
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